What we’ve published…

Selected Publications

Synaptic Adaptation

Quantitative Biology and Modeling

Neural Computation

Synaptic Dysfunction and Disease

Preprints

Complete Publication Record

A complete publication list is available on Google Scholar.

*: equal contribution, #: corresponding author

Research Articles

Vold, A.M., Yang, J., Østergaard, M., Schrøder Lassen, A., Kádková, A., Kumar, A., Walter, A.M., Zhang, Y., Sørensen, J.B. (2026)

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring

Cell Reports https://doi.org/10.1016/j.celrep.2025.116870

Blaum, N., Ghelani, T., Gotz, T., Chronister, K.S., Bengochea, M., Christensen, C.F., Moulin, T.C., Ceresnova, L., Kern, H., Thomas, U., Heine, M., Sigrist, S.J., and Walter, A.M.# (2025)

Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.

Proc Natl Acadam Sci U S A https://10.1073/pnas.2514151122

Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025)

Parameter Optimization for a Neurotransmission Recovery Model

Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2

Berns, M.M.M.#, Yildiz, M., Winkelmann., S., and Walter, A.M.# (2025)

Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane

J Physiol https://doi.org/10.1113/jp286651

Lutzkendorf J., Matkovic-Rachid T., Liu S., Gotz T., Gao L,. Turrel O., Maglione M., Grieger M., Putignano S., Ramesh N., Ghelani T., Neumann A., Gimber N., Schmoranzer J., Stawrakakis A., Brence B., Baum D., Ludwig K., Heine M., Mielke T., Liu F., Walter A.M., Wahl M.C., and Sigrist S.J. (2025)

Blobby is a synaptic active zone assembly protein required for memory in Drosophila

Nat Commun 16, 271 https://doi.org/10.1038/s41467-024-55382-9

Wu, Z, Kusick, G.F., Berns, M.M., Raychaudhuri, S, Kie, I., Walter, A.M., Chapman, E.R., and Watanabe, S. (2024)

Synaptotagmin 7 docks synaptic vesicles for Doc2a-triggered asynchronous neurotransmitter release.

eLife https://doi.org/10.7554/eLife.90632.1

Ernst, A., Ungera, N., Schuette, C., Walter, A.M.#, and Winkelmann, C.# (2023)

Rate-limiting recovery processes in neurotransmission under sustained stimulation

Mathematical Biosciences https://doi.org/10.1016/j.mbs.2023.109023

Jusyte, M., Blaum, N., Böhme, M.A., Berns, M.M.M., Bonard, A.E., Vamosi, A., Pushpalatha, K.V., Kobbersmed, J.R.L., and Walter, A.M.# (2023)

Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation.

Cell Reports https://doi.org/10.1016/j.celrep.2023.112541

Grasskamp A.T., Jusyte, M., McCarthy, A.W., Götz, T.W.B., Susanne Ditlevsen, and Walter, A.M.# (2023)

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials.

Fronties in Cellular Neuroscience doi:10.3389/fncel.2023.1129417

Ghelani, T., Escher, M., Thomas, U., Esch, K., Luetzkendorf, J., Depner, H., Maglione, M., Parutto, P., Gratz, S., Ryglewski, S., Walter, A.M., Holcmann, D., O’Connor Giles, K., Heine, M., and Sigrist, S. (2023)

An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity

Science Advances https://doi.org/10.1126/sciadv.ade7804

Kobbersmed, J.R.L, Berns, M.M.M, Ditlevsen, S., Sørensen, J.B., and Walter, A.M.# (2022)

Allosteric stabilization of calcium and lipid binding engages several synaptotagmins in fast exocytosis

eLife https://doi.org/10.7554/eLife.74810

Bohme, M. A., McCarthy, A. W., Blaum, N., Berezeckaja, M., Ponimaskine, K., Schwefel, D., and Walter, A. M.# (2021)

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function.

Glia; doi: https://doi.org/10.1002/glia.24000 

 Schumacher, M., Grasskamp, A.T., Barahtjan, P., Wagner, N., Lombardot, B., Schumacher, J., S., Lohmann, A., Henry, I., Shevchenko, A., Coskun, Ü., Walter, A.M.#, and Nadler, A.# (2020)

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities.

PNAS doi: 10.1073/pnas.1912684117

Kobbersmed, J.R.L., Grasskamp, A.T., Jusyte, M., Böhme, M.A., Ditlevsen, S., Sørensen, J.B., and Walter, A.,M.# (2020)

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances.

eLife 9, e51032, https://doi.org/10.7554/eLife.51032

Goel, P., Dufour Bergeron, D., Böhme, M.A., Nunnelly, L., Buser, C., Lehmann, M., Walter, A.M., Sigrist, S.J., and Dickman, D. (2019)

Homeostatic scaling of active zone size stabilizes synaptic strength.

J. Cell. Biol. doi: 10.1083/jcb.201807165

Böhme, M. A., McCarthy, A. W., Grasskamp, A. T., Beuschel, C. B., Goel, P., Jusyte, M., Laber, D., Huang, S., Rey, U., Petzold, A., Lehmann, M., Göttfert, F., Haghighi, P., Hell, S. W., Owald, D., Dickman, D., Sigrist, S. J., and Walter, A.M.# (2019)

Rapid active zone remodeling consolidates presynaptic potentiation.

Nat. Commun. 10, 1085, https://doi.org/10.1038/s41467-019-08977-6

Fulterer, A., Andlauer, T.F.M., Ender, A., Maglione, M., Eyring, K., Woitkuhn, J., Lehmann, Matkovic, T., Geiger, J.R.P., Walter, A.M., Nagel, K., and Sigrist, S.J. (2018)

Active zone scaffold protein ratios tune functional diversity across brain synapses.

Cell Reports https://doi.org/10.1016/j.celrep.2018.03.126

Walter, A. M.#, Muller, R., Tawfik, B., Wierda, K. D., Pinheiro, P. S., Nadler, A., McCarthy, A. W., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Lehmann, M., Haucke, V., Hille, B., Schultz, C., and Sorensen, J. B. (2017)

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

eLife 6, e30203, https://doi.org/10.7554/eLife.30203

Reddy-Alla, S., Bohme, M. A., Reynolds, E., Beis, C., Grasskamp, A. T., Mampell, M. M., Maglione, M., Jusyte, M., Rey, U., Babikir, H., McCarthy, A. W., Quentin, C., Matkovic, T., Bergeron, D. D., Mushtaq, Z., Gottfert, F., Owald, D., Mielke, T., Hell, S. W., Sigrist, S. J., and Walter, A. M.# (2017)

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Neuron 95, 1350-1364 e1312, https://doi.org/10.1016/j.neuron.2017.08.016

Grauel, M. K., Maglione, M., Reddy-Alla, S., Willmes, C. G., Brockmann, M. M., Trimbuch, T., Rosenmund, T., Pangalos, M., Vardar, G., Stumpf, A., Walter, A. M., Rost, B. R., Eickholt, B. J., Haucke, V., Schmitz, D., Sigrist, S. J., and Rosenmund, C. (2016)

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Proc Natl Acad Sci U S A. 113, 11615-11620, https://doi.org/10.1073/pnas.1605256113

Bohme, M. A., Beis, C., Reddy-Alla, S., Reynolds, E., Mampell, M. M., Grasskamp, A. T., Lutzkendorf, J., Bergeron, D. D., Driller, J. H., Babikir, H., Gottfert, F., Robinson, I. M., O'Kane, C. J., Hell, S. W., Wahl, M. C., Stelzl, U., Loll, B., Walter, A. M. *#, and Sigrist, S. J.*# (2016)

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Nat Neurosci. 19, 1311-1320, https://doi.org/10.1038/nn.4364

Man, K. N., Imig, C., Walter, A. M., Pinheiro, P. S., Stevens, D. R., Rettig, J., Sorensen, J. B., Cooper, B. H., Brose, N., and Wojcik, S. M. (2015)

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

eLife 4, e10635, https://doi.org/10.7554/eLife.10635

Muhammad, K., Reddy-Alla, S., Driller, J. H., Schreiner, D., Rey, U., Bohme, M. A., Hollmann, C., Ramesh, N., Depner, H., Lutzkendorf, J., Matkovic, T., Gotz, T., Bergeron, D. D., Schmoranzer, J., Goettfert, F., Holt, M., Wahl, M. C., Hell, S. W., Scheiffele, P., Walter, A. M., Loll, B., and Sigrist, S. J. (2015)

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

Nat Commun. 6, 8362, https://doi.org/10.1038/ncomms9362

Schotten, S.*, Meijer, M.*, Walter, A. M.*, Huson, V., Mamer, L., Kalogreades, L., ter Veer, M., Ruiter, M., Brose, N., Rosenmund, C., Sorensen, J. B., Verhage, M., and Cornelisse, L. N. (2015)

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

eLife 4, https://doi.org/10.7554/eLife.05531

Kononenko, N. L., Puchkov, D., Classen, G. A., Walter, A. M., Pechstein, A., Sawade, L., Kaempf, N., Trimbuch, T., Lorenz, D., Rosenmund, C., Maritzen, T., and Haucke, V. (2014)

Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.

Neuron 82, 981-988, https://doi.org/10.1016/j.neuron.2014.05.007

Walter, A. M., Kurps, J., de Wit, H., Schoning, S., Toft-Bertelsen, T. L., Lauks, J., Ziomkiewicz, I., Weiss, A. N., Schulz, A., Fischer von Mollard, G., Verhage, M., and Sorensen, J. B. (2014)

The SNARE protein vti1a functions in dense-core vesicle biogenesis.

The EMBO journal 33, 1681-1697, https://doi.org/10.15252/embj.201387549

Podufall, J., Tian, R., Knoche, E., Puchkov, D., Walter, A. M., Rosa, S., Quentin, C., Vukoja, A., Jung, N., Lampe, A., Wichmann, C., Bohme, M., Depner, H., Zhang, Y. Q., Schmoranzer, J., Sigrist, S. J., and Haucke, V. (2014)

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

Cell reports 7, 1417-1425, https://doi.org/10.1016/j.celrep.2014.04.051

Walter, A. M.#, Pinheiro, P. S., Verhage, M., and Sorensen, J. B.# (2013)

A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion.

PLoS Comp Biol. 9, e1003362, https://doi.org/10.1371/journal.pcbi.1003362

Pinheiro, P. S., de Wit, H., Walter, A. M., Groffen, A. J., Verhage, M., and Sorensen, J. B. (2013)

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release.

J Neurosci. 33, 16459-16470, https://doi.org/10.1523%2FJNEUROSCI.2656-13.2013

Ngatchou, A. N., Kisler, K., Fang, Q., Walter, A. M., Zhao, Y., Bruns, D., Sorensen, J. B., and Lindau, M. (2010)

Role of the synaptobrevin C terminus in fusion pore formation.

Proc Natl Acad Sci U S A. 107, 18463-18468, https://doi.org/10.1073/pnas.1006727107

Wiederhold, K., Kloepper, T. H., Walter, A. M., Stein, A., Kienle, N., Sorensen, J. B., and Fasshauer, D. (2010)

A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.

J Biol Chem. 285, 21549-21559, https://doi.org/10.1074%2Fjbc.M110.105148

Walter, A. M., Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J. B. (2010)

Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis.

J Cell Biol. 188, 401-413, https://doi.org/10.1083%2Fjcb.200907018

de Wit, H., Walter, A. M., Milosevic, I., Gulyas-Kovacs, A., Riedel, D., Sorensen, J. B., and Verhage, M. (2009)

Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes.

Cell 138, 935-946, https://doi.org/10.1016/j.cell.2009.07.027

Nagy, G., Milosevic, I., Mohrmann, R., Wiederhold, K., Walter, A. M., and Sorensen, J. B. (2008)

The SNAP-25 linker as an adaptation toward fast exocytosis.

Mol Biol Cell 19, 3769-3781, https://doi.org/10.1091%2Fmbc.E07-12-1218

Gabriel, J. P., Mahmood, R., Walter, A. M., Kyriakatos, A., Hauptmann, G., Calabrese, R. L., and El Manira, A. (2008)

Locomotor pattern in the adult zebrafish spinal cord in vitro.

J Neurophysiol. 99, 37-48, https://doi.org/10.1152/jn.00785.2007

Reviews, Perspectives & Editorials

Walter, A.M., Uesaka, N., and Midorikawa, M. (2023)

Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.

Frontiers in Cellular Neuroscience https://doi.org/10.3389/fncel.2023.1213640

Bohme, M. A., Grasskamp, A. T., and Walter, A. M. # (2018)

Regulation of synaptic release-site-Ca2+-channel coupling as a mechanism to control release probability and short-term plasticity.

FEBS Lett https://doi.org/10.1002/1873-3468.13188

Walter, A. M.#, Bohme, M.A., and Sigrist, S. J. (2018)

Vesicle release site organization at synaptic active zones.

Neuroscience Research 127, 3-13, https://doi.org/10.1016/j.neures.2017.12.006

Walter, A. M.#, Haucke, V.#, and Sigrist, S. J.# (2014)

Neurotransmission: spontaneous and evoked release filing for divorce.

Current biology: CB 24, R192-194, https://doi.org/10.1016/j.cub.2014.01.037

Walter, A. M., Groffen, A. J., Sorensen, J. B., and Verhage, M. (2011)

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Trends Neurosci. 34, 487-497, https://doi.org/10.1016/j.tins.2011.07.003