Functional relevance of mobile and clustered CaV2.1 channels in central synapses

Functional relevance of mobile and clustered CaV2.1 channels in central synapses

Abderazzaq K.E, Amaral C., Lassen A.S., Weißbach S., Werkmann C., Bikbaev A., Mark M.D., Herlitze S., Heck J., Walter A.M., and Martin Heine

under review at Science Advances. Preprint on BioRXi.

Undoing of firing rate adaptation enables invariant population codes

Undoing of firing rate adaptation enables invariant population codes

Brando S.C., Ramirez L., Züfle P., Walter A.M., Silies M., and Martelli C.

in press at Science Advances, 2026. Preprint on bioRXiV

Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation

Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation

Natalie Blaum, Tina Ghelani, Torsten W. B. Götz, Keagan S. Chronister, Mercedes Bengochea, Livia Ceresnova, Christian F. Christensen, Thiago C. Moulin, Hanna Kern, Ulrich Thomas, Martin Heine, Stephan J. Sigrist, and Alexander M. Walter

Proceedings of the National Academy of Science, Vol. 122 | No. 34 https://doi.org/10.1073/pnas.2514151122

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring

Victora Amstrup Vold, Jie Yang, Maiken Østergaard, Anna Schrøder Lassen, Anna Kádková, Avinash Kumar, Alexander Matthias Walter, Yongli Zhang, Jakob Baslev Sørensen

Cell Reports, Volume 45, Issue 2 https://doi.org/10.1016/j.celrep.2025.116870

"Parameter Optimization for a Neurotransmission Recovery Model"

"Parameter Optimization for a Neurotransmission Recovery Model"

Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025)

Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2

Blobby is a synaptic active zone assembly protein required for memory in Drosophila

Blobby is a synaptic active zone assembly protein required for memory in Drosophila

Lutzkendorf J., Matkovic-Rachid T., Liu S., Gotz T., Gao L,. Turrel O., Maglione M., Grieger M., Putignano S., Ramesh N., Ghelani T., Neumann A., Gimber N., Schmoranzer J., Stawrakakis A., Brence B., Baum D., Ludwig K., Heine M., Mielke T., Liu F., Walter A.M., Wahl M.C., and Sigrist S.J. (2025)

Nat Commun 16, 271 https://doi.org/10.1038/s41467-024-55382-9

Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane

Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane

Berns, M.M.M.#, Yildiz, M., Winkelmann., S., and Walter, A.M.# (2025)

J Physiol https://doi.org/10.1113/jp286651

Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

Zhenyong Wu, Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe

eLife, March 2024

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Götz, Susanne Ditlevsen and Alexander M. Walter

Frontiers in cellular neuroscience, March 2023

Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation

Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation

Meida Jusyte, Natalie Blaum, Mathias A. Bohme, Manon M.M. Berns, Alix E. Bonard, Abel B. Vamosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, and Alexander M. Walter

Cell reports, June 2023

Rate-limiting recovery processes in neurotransmission under sustained stimulation

Rate-limiting recovery processes in neurotransmission under sustained stimulation

Ernst, A., Unger, N., Schütte, C., Walter, A. M., & Winkelmann, S. (2023).

Mathematical biosciences. https://doi.org/10.1016/j.mbs.2023.109023

Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.

Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.

Walter, A.M., Uesaka, N., and Midorikawa, M. (2023)

Frontiers in Cellular Neurosciencehttps://doi.org/10.3389/fncel.2023.1213640

An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity

An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity

Ghelani, T., Escher, M., Thomas, U., Esch, K., Luetzkendorf, J., Depner, H., Maglione, M., Parutto, P., Gratz, S., Ryglewski, S., Walter, A.M., Holcmann, D., O’Connor Giles, K., Heine, M., and Sigrist, S. (2023)

Science Advances https://doi.org/10.1126/sciadv.ade7804

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter

Elife, Aug. 2022

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

Mathias A Böhme, Anthony W McCarthy, Natalie Blaum, Monika Berezeckaja , Kristina Ponimaskine, David Schwefel, Alexander M Walter

Glia, sep 2021

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

Milena Schuhmacher, Andreas T. Grasskamp, Pavel Barahtjan, Nicolai Wagner, Benoit Lombardot, Jan S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander M. Walter, and André Nadler

PNAS, March 2020

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter

eLife, Feb 2020

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter

Nature Communications, March 2019

Homeostatic scaling of active zone scaffolds maintains global synaptic strength

Homeostatic scaling of active zone scaffolds maintains global synaptic strength

Pragya Goel, Dominique Dufour Bergeron, Mathias A. Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M. Walter, Stephan J. Sigrist, Dion Dickman

Journal of Cell Biology, March 2019

Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity

Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity

Mathias A Böhme, Andreas T Grasskamp, Alexander M Walter

FEBS Letters, July 2018

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses

Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel and Stephan J. Sigrist

Cell Reports, May 2018

Vesicle release site organization at synaptic active zones

Vesicle release site organization at synaptic active zones

Alexander M. Walter, Mathias A. Böhme, Stephan J. Sigrist

Neuroscience Research, December 2017

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen

eLife, October 2017

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Nature Communications, March 2019

Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter

Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission

Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission

Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter

Neuron, September 2017

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

M. Katharina Grauel, Marta Maglione, Suneel Reddy-Alla, Claudia G. Willmes, Marisa M. Brockmann, Thorsten Trimbuch, Tanja Rosenmund, Maria Pangalos, Gülçin Vardar, Alexander Stumpf, Alexander M. Walter, Benjamin R. Rost, Britta J. Eickholt, Volker Haucke, Dietmar Schmitz, Stephan J. Sigrist, and Christian Rosenmund

PNAS, 2016

Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling

Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling

Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Nature Neuroscience, August 2016

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik

eLIFE, 2015

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter, Bernhard Loll & Stephan J. Sigrist

Nat Commun., 2015

The SNARE protein vti1a functions in dense-core vesicle biogenesis

The SNARE protein vti1a functions in dense-core vesicle biogenesis

Alexander M Walter, Julia Kurps, Heidi de Wit, Susanne Schöning, Trine L Toft‐Bertelsen, Juliane Lauks, Iwona Ziomkiewicz, Annita N Weiss, Alexander Schulz, Gabriele Fischer von Mollard, Matthijs Verhage, Jakob B Sørensen

EMBO J., Aug 1, 2014

Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses

Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses

Kononenko N.L., Puchkov D., Classen G.A., Walter A.M., Pechstein A., Sawade L., Kaempf N., Trimbuch T., Lorenz D., Rosenmund C., Maritzen T., Haucke V.

Neuron, Jun 4, 2014

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling

Cell Reports, Jun 12, 2014

Podufall J., Tian R., Knoche E., Puchkov D., Walter A.M., Rosa S., Quentin C., Vukoja A., Jung N., Lampe A., Wichmann C., Böhme M., Depner H., Zhang Y.Q., Schmoranzer J., Sigrist S.J., Haucke V.

Neurotransmission: Spontaneous and Evoked Release Filing for Divorce

Neurotransmission: Spontaneous and Evoked Release Filing for Divorce

Current Biology, Mar 3, 2014

Walter, A.M. , Haucke, V., and Sigrist, S.J.

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion

Walter, A.M. , Pinheiro, P.S., Verhage, M., and Sorensen, J.B.

PLoS Comp Biol, Dec 5, 2013

Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release

Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release

Paulo S. Pinheiro, Heidi de Wit, Alexander M. Walter, Alexander J. Groffen, Matthijs Verhage and Jakob B. Sørensen

J Neurosci, Oct 16, 2013

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Walter A.M., Groffen A.J., Sørensen J.B., Verhage M.

Trends Neurosci., Sep 2011

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

Walter, A.M. , Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J.B.

J Cell Biol, Jan 2010

Role of the synaptobrevin C terminus in fusion pore formation

Role of the synaptobrevin C terminus in fusion pore formation

Ngatchou, A.N., Kisler, K., Fang, Q., Walter, A.M., Zhao, Y., Bruns, D., Sorensen, J.B., and Lindau, M.

Proc Natl Acad Sci U S A, Oct 26, 2010

A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex

A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex

Wiederhold, K., Kloepper, T. H., Walter, A. M., Stein, A., Kienle, N., Sorensen, J. B., and Fasshauer, D.

J Biol Chem, Jul 9, 2010

Active zone remodeling by Bruchpilot couples synaptic architecture to Kv1/Shaker excitability control

Active zone remodeling by Bruchpilot couples synaptic architecture to Kv1/Shaker excitability control

Huang S., Piao C., Escher M., Toppe D., Beuschel C.B., Götz T., Ramesh N., Zhao Z., Turrel O., Walter A.M., Liu F., and Sigrist S.J.

In revision for Science Advances. Preprint on BioRXiv.

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Previous Next
Functional relevance of mobile and clustered CaV2.1 channels in central synapses
Undoing of firing rate adaptation enables invariant population codes
Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation
SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring
"Parameter Optimization for a Neurotransmission Recovery Model"
Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Rate-limiting recovery processes in neurotransmission under sustained stimulation
Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.
An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity
Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses
Vesicle release site organization at synaptic active zones
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
The SNARE protein vti1a functions in dense-core vesicle biogenesis
Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses
A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling
Neurotransmission: Spontaneous and Evoked Release Filing for Divorce
A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion
Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
Role of the synaptobrevin C terminus in fusion pore formation
A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex
Active zone remodeling by Bruchpilot couples synaptic architecture to Kv1/Shaker excitability control