Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation
“Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation”
Proceedings of the National Academy of Science, Vol. 122 | No. 34 https://doi.org/10.1073/pnas.2514151122
"Parameter Optimization for a Neurotransmission Recovery Model"
Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025)
Parameter Optimization for a Neurotransmission Recovery Model
Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2
Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Lutzkendorf J., Matkovic-Rachid T., Liu S., Gotz T., Gao L,. Turrel O., Maglione M., Grieger M., Putignano S., Ramesh N., Ghelani T., Neumann A., Gimber N., Schmoranzer J., Stawrakakis A., Brence B., Baum D., Ludwig K., Heine M., Mielke T., Liu F., Walter A.M., Wahl M.C., and Sigrist S.J. (2025)
Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Nat Commun 16, 271 https://doi.org/10.1038/s41467-024-55382-9
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Rate-limiting recovery processes in neurotransmission under sustained stimulation
Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.
Walter, A.M., Uesaka, N., and Midorikawa, M. (2023)
Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling.
Frontiers in Cellular Neuroscience https://doi.org/10.3389/fncel.2023.1213640
Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane
Berns, M.M.M.#, Yildiz, M., Winkelmann., S., and Walter, A.M.# (2025)
Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane
J Physiolhttps://doi.org/10.1113/jp286651
An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity
Ghelani, T., Escher, M., Thomas, U., Esch, K., Luetzkendorf, J., Depner, H., Maglione, M., Parutto, P., Gratz, S., Ryglewski, S., Walter, A.M., Holcmann, D., O’Connor Giles, K., Heine, M., and Sigrist, S. (2023)
An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity
Science Advances https://doi.org/10.1126/sciadv.ade7804
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Rate-limiting recovery processes in neurotransmission under sustained stimulation
Ernst, A., Unger, N., Schütte, C., Walter, A. M., & Winkelmann, S. (2023).
Rate-limiting recovery processes in neurotransmission under sustained stimulation.
Mathematical biosciences. https://doi.org/10.1016/j.mbs.2023.109023
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Elife, Aug. 2022
Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glia, sep 2021
Mathias A Böhme, Anthony W McCarthy, Natalie Blaum, Monika Berezeckaja , Kristina Ponimaskine, David Schwefel, Alexander M Walter
Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
PNAS, March 2020
Milena Schuhmacher, Andreas T. Grasskamp, Pavel Barahtjan, Nicolai Wagner, Benoit Lombardot, Jan S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander M. Walter, and André Nadler
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances
eLife, Feb 2020
Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Nature Communications, March 2019
Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter
Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Journal of Cell Biology, March 2019
Pragya Goel, Dominique Dufour Bergeron, Mathias A. Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M. Walter, Stephan J. Sigrist, Dion Dickman
Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity
FEBS Letters, July 2018
Mathias A Böhme, Andreas T Grasskamp, Alexander M Walter
Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses
Cell Reports, May 2018
Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel and Stephan J. Sigrist
Vesicle release site organization at synaptic active zones
Neuroscience Research, December 2017
Alexander M. Walter, Mathias A. Böhme, Stephan J. Sigrist
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
eLife, October 2017
Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen
Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission
Neuron, September 2017
Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
PNAS, 2016
M. Katharina Grauel, Marta Maglione, Suneel Reddy-Alla, Claudia G. Willmes, Marisa M. Brockmann, Thorsten Trimbuch, Tanja Rosenmund, Maria Pangalos, Gülçin Vardar, Alexander Stumpf, Alexander M. Walter, Benjamin R. Rost, Britta J. Eickholt, Volker Haucke, Dietmar Schmitz, Stephan J. Sigrist, and Christian Rosenmund
Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling
Nature Neuroscience, August 2016
Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
eLIFE, 2015
Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
Nat Commun., 2015
Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter, Bernhard Loll & Stephan J. Sigrist
Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
eLIFE, 2015
Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson, Lauren Mamer, Lawrence Kalogreades, Mirelle ter Veer, Marvin Ruiter, Nils Brose, Christian Rosenmund, Jakob Balslev Sørensen, Matthijs Verhage, Lennart Niels Cornelisse
The SNARE protein vti1a functions in dense-core vesicle biogenesis
EMBO J., Aug 1, 2014
Alexander M Walter, Julia Kurps, Heidi de Wit, Susanne Schöning, Trine L Toft‐Bertelsen, Juliane Lauks, Iwona Ziomkiewicz, Annita N Weiss, Alexander Schulz, Gabriele Fischer von Mollard, Matthijs Verhage, Jakob B Sørensen
Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses
Neuron, Jun 4, 2014
Kononenko N.L., Puchkov D., Classen G.A., Walter A.M., Pechstein A., Sawade L., Kaempf N., Trimbuch T., Lorenz D., Rosenmund C., Maritzen T., Haucke V.
A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling
Cell Reports, Jun 12, 2014
Podufall J., Tian R., Knoche E., Puchkov D., Walter A.M., Rosa S., Quentin C., Vukoja A., Jung N., Lampe A., Wichmann C., Böhme M., Depner H., Zhang Y.Q., Schmoranzer J., Sigrist S.J., Haucke V.
Neurotransmission: Spontaneous and Evoked Release Filing for Divorce
Current Biology, Mar 3, 2014
Walter, A.M. , Haucke, V., and Sigrist, S.J.
A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion
PLoS Comp Biol, Dec 5, 2013
Walter, A.M. , Pinheiro, P.S., Verhage, M., and Sorensen, J.B.
Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release
J Neurosci, Oct 16, 2013
Paulo S. Pinheiro, Heidi de Wit, Alexander M. Walter, Alexander J. Groffen, Matthijs Verhage and Jakob B. Sørensen
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
Trends Neurosci., Sep 2011
Walter A.M., Groffen A.J., Sørensen J.B., Verhage M.
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
J Cell Biol, Jan 2010
Walter, A.M. , Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J.B.
Role of the synaptobrevin C terminus in fusion pore formation
Proc Natl Acad Sci U S A, Oct 26, 2010
Ngatchou, A.N., Kisler, K., Fang, Q., Walter, A.M., Zhao, Y., Bruns, D., Sorensen, J.B., and Lindau, M.
A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex
J Biol Chem, Jul 9, 2010
Wiederhold, K., Kloepper, T. H., Walter, A. M., Stein, A., Kienle, N., Sorensen, J. B., and Fasshauer, D.
