https://www.walter-lab.com/all-publications-gallery daily 0.75 2026-07-26 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1718967472274-PQ67HLWXJI2JC7T2P4OO/image-asset.jpeg All Publications - Dr. Manon Berns Defended Her Ph.D.!! We at the Walter Lab would like to congratulate Dr. Manon Berns for an amazing defense of her Ph.D. Dissertation on the "Molecular Mechanisms of Synaptic Transmission Investigated Using Mathematical Models". She has worked so hard these last few years, and it's no surprise she has achieved her Doctorate! We wish her the best to her and her future endeavors. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1718967472274-PQ67HLWXJI2JC7T2P4OO/image-asset.jpeg All Publications - Dr. Manon Berns Defended Her Ph.D.!! We at the Walter Lab would like to congratulate Dr. Manon Berns for an amazing defense of her Ph.D. Dissertation on the "Molecular Mechanisms of Synaptic Transmission Investigated Using Mathematical Models". She has worked so hard these last few years, and it's no surprise she has achieved her Doctorate! We wish her the best to her and her future endeavors. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785019780581-SCEV8TSGL3EW5CVT6YWO/image-asset.jpg All Publications - Functional relevance of mobile and clustered CaV2.1 channels in central synapses Abderazzaq K.E, Amaral C., Lassen A.S., Weißbach S., Werkmann C., Bikbaev A., Mark M.D., Herlitze S., Heck J., Walter A.M., and Martin Heine under review at Science Advances. Preprint on BioRXi. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785093122866-B2F2TCIE2SMPP51Z62C1/image-asset.jpeg All Publications - Undoing of firing rate adaptation enables invariant population codes Brando S.C., Ramirez L., Züfle P., Walter A.M., Silies M., and Martelli C. in press at Science Advances, 2026. Preprint on bioRXiV https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785077176043-RWFDNCYGJUQ6IA5DIYUF/image-asset.png All Publications - Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation Natalie Blaum, Tina Ghelani, Torsten W. B. Götz, Keagan S. Chronister, Mercedes Bengochea, Livia Ceresnova, Christian F. Christensen, Thiago C. Moulin, Hanna Kern, Ulrich Thomas, Martin Heine, Stephan J. Sigrist, and Alexander M. Walter Proceedings of the National Academy of Science, Vol. 122 | No. 34 https://doi.org/10.1073/pnas.2514151122 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1774275941353-KVT6ZGSPU004IRZ67ZDI/Screenshot+2026-03-23+152211.png All Publications - SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring Victora Amstrup Vold, Jie Yang, Maiken Østergaard, Anna Schrøder Lassen, Anna Kádková, Avinash Kumar, Alexander Matthias Walter, Yongli Zhang, Jakob Baslev Sørensen Cell Reports, Volume 45, Issue 2 https://doi.org/10.1016/j.celrep.2025.116870 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753261567966-CMFQ87ECIFWXKXRCXXFT/image-asset.jpeg All Publications - "Parameter Optimization for a Neurotransmission Recovery Model" Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025) Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753190706612-BCO9O07B8YPY9DJ5T9S6/image-asset.png All Publications - Blobby is a synaptic active zone assembly protein required for memory in Drosophila Lutzkendorf J., Matkovic-Rachid T., Liu S., Gotz T., Gao L,. Turrel O., Maglione M., Grieger M., Putignano S., Ramesh N., Ghelani T., Neumann A., Gimber N., Schmoranzer J., Stawrakakis A., Brence B., Baum D., Ludwig K., Heine M., Mielke T., Liu F., Walter A.M., Wahl M.C., and Sigrist S.J. (2025) Nat Commun 16, 271 https://doi.org/10.1038/s41467-024-55382-9 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753188822749-EE7KC2JV81NFUDMI5LMS/manon+paper.png All Publications - Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane Berns, M.M.M.#, Yildiz, M., Winkelmann., S., and Walter, A.M.# (2025) J Physiol https://doi.org/10.1113/jp286651 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1714982174133-S9SZZX1XQST2T07LS7MS/lax%2B90632_elife-90632-fig2-v1.tif.jpg All Publications - Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release Zhenyong Wu, Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe eLife, March 2024 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1686559987163-OD53DNRJ7XFI6H9WLN9U/image-asset.jpeg All Publications - Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Götz, Susanne Ditlevsen and Alexander M. Walter Frontiers in cellular neuroscience, March 2023 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1686559517101-4PQZC7JS9GS7JK9MLL3F/Screenshot+2023-06-12+102623.png All Publications - Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation Meida Jusyte, Natalie Blaum, Mathias A. Bohme, Manon M.M. Berns, Alix E. Bonard, Abel B. Vamosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, and Alexander M. Walter Cell reports, June 2023 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1687955893825-078MUFXRPKO7JWVOT408/image-asset.jpeg All Publications - Rate-limiting recovery processes in neurotransmission under sustained stimulation Ernst, A., Unger, N., Schütte, C., Walter, A. M., & Winkelmann, S. (2023). Mathematical biosciences. https://doi.org/10.1016/j.mbs.2023.109023 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753261647880-R9PJGK5QJT8SRARIQZI4/image-asset.jpeg All Publications - Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling. Walter, A.M., Uesaka, N., and Midorikawa, M. (2023) Frontiers in Cellular Neurosciencehttps://doi.org/10.3389/fncel.2023.1213640 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753190919256-1GZPQGC12TGXW3SC2PDV/image-asset.png All Publications - An active zone state switch concentrates and immobilizes voltage gated Ca2+ channels to promote long-term plasticity Ghelani, T., Escher, M., Thomas, U., Esch, K., Luetzkendorf, J., Depner, H., Maglione, M., Parutto, P., Gratz, S., Ryglewski, S., Walter, A.M., Holcmann, D., O’Connor Giles, K., Heine, M., and Sigrist, S. (2023) Science Advances https://doi.org/10.1126/sciadv.ade7804 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661427453887-IRWKV7WCZV9D5TV2XG0C/StrikingImage.png All Publications - Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter Elife, Aug. 2022 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785083647301-XQBAZC8PM7YI9LLSXV0D/unsplash-image-Oaqk7qqNh_c.jpg All Publications - Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function Mathias A Böhme, Anthony W McCarthy, Natalie Blaum, Monika Berezeckaja , Kristina Ponimaskine, David Schwefel, Alexander M Walter Glia, sep 2021 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1586353231562-PXQH6LYFFG05RRUKMGY6/image-asset.jpeg All Publications - Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter eLife, Feb 2020 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785083120268-4TCWIYH1TGJCWHY423UX/image-asset.png All Publications - Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities Milena Schuhmacher, Andreas T. Grasskamp, Pavel Barahtjan, Nicolai Wagner, Benoit Lombardot, Jan S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander M. Walter, and André Nadler PNAS, March 2020 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785081414339-3XWC5ICLALVJRV9GU56P/image-asset.png All Publications - Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter eLife, Feb 2020 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489425888-L0JE3N15ALSL7YUV57GC/NatComm2019.jpg All Publications - Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter Nature Communications, March 2019 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489425876-SKZ7PM2U4G0GW63XX5EI/image-asset.jpeg All Publications - Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation Nature Communications, March 2019 Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578571998264-ZJ6GLEWXXP26KLEAGDTE/image-asset.jpeg All Publications - Homeostatic scaling of active zone scaffolds maintains global synaptic strength Pragya Goel, Dominique Dufour Bergeron, Mathias A. Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M. Walter, Stephan J. Sigrist, Dion Dickman Journal of Cell Biology, March 2019 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489389817-IEC8HBN3ROTKCA5KMYAS/FEBS+Review+2018.png All Publications - Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity Mathias A Böhme, Andreas T Grasskamp, Alexander M Walter FEBS Letters, July 2018 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785080311279-Z1LLEONHKEWYBY52LL5A/image-asset.jpeg All Publications - Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel and Stephan J. Sigrist Cell Reports, May 2018 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489259655-YGWZO6SBMPUGSRUJJGM5/NeuSciRes2017.PNG All Publications - Vesicle release site organization at synaptic active zones Alexander M. Walter, Mathias A. Böhme, Stephan J. Sigrist Neuroscience Research, December 2017 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489151326-7JH3BCOWBGSVDUHQUT8V/eLife+2017.PNG All Publications - Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen eLife, October 2017 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785082405206-CF1GE1G5H6TJX62HY9GH/NatComm2019.jpg All Publications - Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation Nature Communications, March 2019 Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489212505-RDWF4W8VKX0CQSGHJ5VF/Neuron+2017.png All Publications - Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter Neuron, September 2017 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578409518618-38XBD54IQEL07A9IJ6H3/image-asset.jpeg All Publications - RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses M. Katharina Grauel, Marta Maglione, Suneel Reddy-Alla, Claudia G. Willmes, Marisa M. Brockmann, Thorsten Trimbuch, Tanja Rosenmund, Maria Pangalos, Gülçin Vardar, Alexander Stumpf, Alexander M. Walter, Benjamin R. Rost, Britta J. Eickholt, Volker Haucke, Dietmar Schmitz, Stephan J. Sigrist, and Christian Rosenmund PNAS, 2016 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489236358-K5IEJP1GQPY28VDCEZVZ/NatNeurosci2016.PNG All Publications - Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist Nature Neuroscience, August 2016 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578409807737-TBWKZDP7154XLXR6NPAF/image-asset.jpeg All Publications - Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik eLIFE, 2015 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578410219733-EILU01CQYEVNCO1SOFY3/image-asset.jpeg All Publications - Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter, Bernhard Loll & Stephan J. Sigrist Nat Commun., 2015 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578495532141-HXFF92RDBKXAATSPC6DQ/image-asset.jpeg All Publications - The SNARE protein vti1a functions in dense-core vesicle biogenesis Alexander M Walter, Julia Kurps, Heidi de Wit, Susanne Schöning, Trine L Toft‐Bertelsen, Juliane Lauks, Iwona Ziomkiewicz, Annita N Weiss, Alexander Schulz, Gabriele Fischer von Mollard, Matthijs Verhage, Jakob B Sørensen EMBO J., Aug 1, 2014 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578573222365-FTHN7OIX7Q6E2RIUBE61/image-asset.jpeg All Publications - Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses Kononenko N.L., Puchkov D., Classen G.A., Walter A.M., Pechstein A., Sawade L., Kaempf N., Trimbuch T., Lorenz D., Rosenmund C., Maritzen T., Haucke V. Neuron, Jun 4, 2014 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578573636736-I7XZDIO326NRWGSG31ZQ/image-asset.jpeg All Publications - A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling Cell Reports, Jun 12, 2014 Podufall J., Tian R., Knoche E., Puchkov D., Walter A.M., Rosa S., Quentin C., Vukoja A., Jung N., Lampe A., Wichmann C., Böhme M., Depner H., Zhang Y.Q., Schmoranzer J., Sigrist S.J., Haucke V. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578573991377-TC3UXSHOFE7AAOXO79GX/image-asset.jpeg All Publications - Neurotransmission: Spontaneous and Evoked Release Filing for Divorce Current Biology, Mar 3, 2014 Walter, A.M. , Haucke, V., and Sigrist, S.J. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785082651165-SG6PEA050TGSEE7HOEUE/image-asset.png All Publications - A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion Walter, A.M. , Pinheiro, P.S., Verhage, M., and Sorensen, J.B. PLoS Comp Biol, Dec 5, 2013 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578574596455-KVY5MS6XLNLPP0ANOCER/image-asset.jpeg All Publications - Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release Paulo S. Pinheiro, Heidi de Wit, Alexander M. Walter, Alexander J. Groffen, Matthijs Verhage and Jakob B. Sørensen J Neurosci, Oct 16, 2013 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578574857092-VJZ1NN65V420MHC8Y169/image-asset.jpeg All Publications - Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? Walter A.M., Groffen A.J., Sørensen J.B., Verhage M. Trends Neurosci., Sep 2011 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578575157446-BJBX0ZCZ1CA7F6IHCE5B/image-asset.jpeg All Publications - Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis Walter, A.M. , Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J.B. J Cell Biol, Jan 2010 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578575511265-L6COV5I6OFXZ13HFZFBJ/image-asset.jpeg All Publications - Role of the synaptobrevin C terminus in fusion pore formation Ngatchou, A.N., Kisler, K., Fang, Q., Walter, A.M., Zhao, Y., Bruns, D., Sorensen, J.B., and Lindau, M. Proc Natl Acad Sci U S A, Oct 26, 2010 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578575842089-D3LOM2VHDZQLH1Q8PBI3/image-asset.jpeg All Publications - A Coiled Coil Trigger Site Is Essential for Rapid Binding of Synaptobrevin to the SNARE Acceptor Complex Wiederhold, K., Kloepper, T. H., Walter, A. M., Stein, A., Kienle, N., Sorensen, J. B., and Fasshauer, D. J Biol Chem, Jul 9, 2010 https://static1.squarespace.com/static/5d8c9ec3b7b88e4b013c2193/5df13149c4c6bc16efd78846/6a661351e419b46140a0abd5/1785081843912/ All Publications - SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring (Copy) Victora Amstrup Vold, Jie Yang, Maiken Østergaard, Anna Schrøder Lassen, Anna Kádková, Avinash Kumar, Alexander Matthias Walter, Yongli Zhang, Jakob Baslev Sørensen “ SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring Cell Reports, Volume 45, Issue 2 https://doi.org/10.1016/j.celrep.2025.116870 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1671530443369-9OTK41NPVQL1NQO3004A/image-asset.png All Publications - Active zone remodeling by Bruchpilot couples synaptic architecture to Kv1/Shaker excitability control Huang S., Piao C., Escher M., Toppe D., Beuschel C.B., Götz T., Ramesh N., Zhao Z., Turrel O., Walter A.M., Liu F., and Sigrist S.J. In revision for Science Advances. Preprint on BioRXiv. https://www.walter-lab.com/about-us daily 1.0 2026-07-26 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/db28792b-ddf4-4c8a-9296-8723404a2603/WalterLabGroupPhoto.jpg About The Lab https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/07b7ccac-73bc-4172-90b0-26e6fa52c8d6/Untitled4.png About The Lab - Make it stand out The Walter Lab aboard a Viking ship, 2026 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1632123431044-PZ1HXUB3EF6PTRJRK2RS/Alex.jpg About The Lab - Prof. Dr. Alexander M. Walter Principal Investigator Quantitative neurophysiology, computational biology, and synaptic plasticity Google Scholar write me an email / call me https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/28290bfd-fc3c-44a7-b116-67d6a3eb2c94/IMG_1648_Kavya.jpg About The Lab - Dr. Kavya Vinayan Pushpalatha Postdoctoral Researcher Cellular & Molecular Neurobiology write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/6a75e006-2919-4296-a1e5-0f8d9d77d814/DSC05491.jpg About The Lab - Dr. Christian Christensen Postdoctoral Researcher Cellular Neurobiology and Behavior write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/36261cfe-4a45-404e-9ec9-fce19347ee27/DSC05501.jpg About The Lab - Anna Schrøder Lassen Research Assistant Computational Biology & Modeling write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/98aacf86-be22-4a3d-8839-9a69d59d69cc/DSC00098.JPG About The Lab - Keagan Scott Chronister, M.Sc. Research Assistant Synaptic Cell Biology and Fly Genetics write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/64dd0752-921c-4e0a-9ca4-f181a743fc4e/IMG_1321.jpg About The Lab - Asger Marschall-Booth Bachelor’s Student Computational Biology & Modeling write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/15158d58-3765-44b9-afa3-4bea51cd14a6/Maider+photo.jpg About The Lab - Maider Gonzalez-Muxika Master’s Student Human Disease Models write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/156ad76e-af0f-4c18-9963-9742878e9d5f/Vera.jpg About The Lab - Dr. Vera Kovaleva Postdoctoral Fellow Human neuronal models and translational neuroscience write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/7dd700c6-19bc-454c-a13d-6bcb41ee55d6/Screenshot+2026-06-10+113311.png About The Lab - Dr. Simone Bærentzen Lab Operations Manager write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/f922d342-0e11-4982-b4da-5127d61eae3e/Pontus.jpg About The Lab - Pontus Uddström, M.Sc. Research Assistant Molecular Neurobiology write me an email https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/6451b8a8-8d49-461e-8fe2-dd88ac210b5e/ResearchProgram1_v2.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/16b00a64-01b6-4640-a725-b7d26637f2d2/IllustrationSTF.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/af4dd661-0937-4b8f-83d2-7b45b0eaa6fe/AdaptiveIllustration.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/a25e03da-59a7-4a8c-9388-9536588debaf/Figure3Large.jpeg About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/c471113c-4c34-44a4-90d2-9ab97b585af9/IllustrationEPhys.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/09bdd1ad-f49e-4db2-84e8-1159779e2605/ModelingIllustration.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/585ce2b9-0a6e-45ad-b8e9-23f1c439fe15/STEimaging.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/86664175-e139-4ad0-bcee-4d196558e854/CrossSpecies.png About The Lab - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.walter-lab.com/featured-publications daily 0.75 2026-07-26 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/ee2f1d33-5ab3-429c-b560-121914e3e947/blaum%2Bpaper.png Featured Publications https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1756281256341-KRMBFIONL5WX0Y760X9T/blaum+paper.png Featured Publications - Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation Natalie Blaum, Tina Ghelani, Torsten W. B. Götz, Keagan S. Chronister, Mercedes Bengochea, Livia Ceresnova, Christian F. Christensen, Thiago C. Moulin, Hanna Kern, Ulrich Thomas, Martin Heine, Stephan J. Sigrist, and Alexander M. Walter “Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation” Proceedings of the National Academy of Science, Vol. 122 | No. 34 https://doi.org/10.1073/pnas.2514151122 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753261697929-DIMZSE16GS8EFB7NHIHP/unsplash-image-4Hg8LH9Hoxc.jpg Featured Publications - "Parameter Optimization for a Neurotransmission Recovery Model" Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025) Parameter Optimization for a Neurotransmission Recovery Model Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753261698100-DR79XSB600NDFPNDRZML/image-asset.jpeg Featured Publications - "Parameter Optimization for a Neurotransmission Recovery Model" Ernst, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A.M.#, and Winkelmann, S.# (2025) Parameter Optimization for a Neurotransmission Recovery Model Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-025-01486-2 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1682931189179-UFPSRX25KRV2K18KJTAG/unsplash-image-lUaaKCUANVI.jpg Featured Publications - Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials Frontiers Cellular Neuroscience, March 2023 Andreas T Grasskamp , Meida Jusyte, Anthony W McCarthy, Torsten W B Götz , Susanne Ditlevsen, Alexander M Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753188822749-EE7KC2JV81NFUDMI5LMS/image-asset.png Featured Publications - Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane Berns, M.M.M.#, Yildiz, M., Winkelmann., S., and Walter, A.M.# (2025) Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane J Physiolhttps://doi.org/10.1113/jp286651 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753189099262-N7W1T6XDOVME7J62ELAY/lax%2B90632_elife-90632-fig2-v1.tif.jpg Featured Publications - Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release eLife, March 2024 Zhenyong Wu,Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1753189234955-IUSKG7KEJ89RT7KIKULX/Screenshot%2B2023-06-12%2B102623.png Featured Publications - Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation Cell reports, June 2023 Meida Jusyte, Natalie Blaum, Mathias A. Bohme, Manon M.M. Berns, Alix E. Bonard, Abel B. Vamosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, and Alexander M. Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1686559577789-5RB740ZKOP2M285OJU2D/image-asset.jpeg Featured Publications - Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials Frontiers in Cellular Neuroscience, March 2023 Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Götz, Susanne Ditlevsen and Alexander M. Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1576319574771-WRBZ9ZE8X1JRLUJJWXZH/NeuSciRes2017.PNG Featured Publications https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661427659176-VJMVNGTGX5SWB6BB26QQ/StrikingImage.png Featured Publications - Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis Elife, aug. 2022 Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1632125920898-C5M72QHX8H3TPK0CTK9O/unsplash-image-5cFwQ-WMcJU.jpg Featured Publications - Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function Glia, sep 2021 Mathias A Böhme , Anthony W McCarthy, Natalie Blaum , Monika Berezeckaja , Kristina Ponimaskine , David Schwefel, Alexander M Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489212505-RDWF4W8VKX0CQSGHJ5VF/Neuron+2017.png Featured Publications - Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission Neuron, September 2017 Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578489236358-K5IEJP1GQPY28VDCEZVZ/NatNeurosci2016.PNG Featured Publications - Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling Nature Neuroscience, August 2016 Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist https://www.walter-lab.com/news daily 0.75 2026-03-23 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1774277976848-FNJ0MSFLKK7HN76E4KZL/DSC05595.JPG News - Lab Update: New Lab Members! We recently have had new lab members join the lab, and would like to give them a warm welcome! We welcome our: Lab Technician: Dorte Lauritsen Student Workers: André Rajoo and Maider Gonzalez Muxika Bachelors Students: Anna Linnea Müllenborn and Asger Marschall-Booth https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1774277976848-FNJ0MSFLKK7HN76E4KZL/DSC05595.JPG News - Lab Update: New Lab Members! We recently have had new lab members join the lab, and would like to give them a warm welcome! We welcome our: Lab Technician: Dorte Lauritsen Student Workers: André Rajoo and Maider Gonzalez Muxika Bachelors Students: Anna Linnea Müllenborn and Asger Marschall-Booth https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1756281256341-KRMBFIONL5WX0Y760X9T/blaum+paper.png News - New Publication! Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation (Click anywhere to open the article in a new tab) We are very excited to present our newest publication on “Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation”. In this publication we show how monoaminergic signaling and the mechanisms underlying this signaling can enhance neurotransmission within one minute and compact active zones by targeting the Unc13 protein. We would like to thank our collaborators Dr. Stephan Sigrist and Dr. Martin Heine for the their support in this publication. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1667829910293-IM5OS9AMCNLC7RTHCOO9/Picture2.png News https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1752497708694-2IGAFN09PLEDQG2DAFJU/image-asset.png News - New Publication! "Parameter Optimization for a Neurotransmission Recovery Model" (Click anywhere on this text for the article) We here would like to present our newest article in collaboration with Dr. Stefanie Winkelmann’s lab on “Parameter Optimization for a Neurotransmission Recovery Model”. This article by Ernst. et al 2025 models data from Meida et al. 2023 (our lab) to understand active zone release sites with a simplified model covering maturation, fusion, and recovery of synapses. We are always looking to collaborate and encourage collaborations, so we hope you enjoy this article. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1745322218395-KE5J17ZRNNP59J6X4DS6/image-asset.jpeg News - Dr. Natalie Blaum Successfully Defended Her Ph.D. Thesis! We would like to give a huge congratulations to Dr. Natalie Blaum for successfully defending her Ph.D. Thesis! Over the past 4 years, she has worked on understanding molecular mechanisms of octopamine mediated synaptic potentiation in the Drosophila melanogaster. This is a huge achievement, and we are so very proud of you, and you did such a wonderful job in your presentation and defending your thesis! We would also like to thank the censors/opponents, Dr. Andrew Frank from the University of Iowa and Dr. David Owald from the Charité Universitätsmedizin in Berlin for their input, advice, and lively discussion. We all enjoyed the discussion. We would also like to thank Dr. Nanna MacAulay for also supporting Natalie throughout her thesis and for her introduction at Natalie’s defense. If you would like to see the projects Natalie worked on in her thesis we will link them below: Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation Again, The Walter Lab is so very proud of Natalie, and are looking forward to what she does in the future! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1737024380672-TY67765WNHX8AEFXI9P4/image-asset.jpeg News - Welcome to Erika, a Neuroscience Academy of Denmark PhD candidate, on rotation We would like to welcome Erika Uddström to the lab as a rotational student in the NAD program! She will be learning how to utilize computational methods to understand how the synapse organizes. Welcome Erika! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1736931162261-CFPXNJDAP4DBIP3QWZP2/image-asset.png News - Manon's Paper is Published! Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane Click here to read more! Using computational modelling, we show that proteins and protein complexes of different lengths, such as synaptotagmin-1, Munc13, and the SNARE complex, as well as their abundance at the active zone can enhance synaptic vesicle trafficking to the plasma membrane https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1730986320582-D3LTYK1XBSRMJLJ8YG1Q/image-asset.jpeg News - New Lab Members: Dr. Bengochea and Pontus! We would like to welcome Dr. Mechi Bengochea and Pontus LeBlanc to the Walter Lab! Dr. Bengochea will be setting up and working on behavioral experiments for the lab, while Pontus will be helping out with our fly husbandry, imaging experiments, and cell culture. We are very excited to have these new members so we can further study neuronal communication and plasticity in the Drosophila melanogaster model organism! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1730295874574-UJFCNJWKIDP4Q884UIC7/image-asset.jpeg News - Symposium in Synapse in Health and Disease in Copenhagen! The Walter Lab is happy to announce that we, in collaboration with the Sørensen Lab, are hosting a Symposium in Synapse in Health and Disease in Copenhagen from January 23- 25, 2025! Join us for an exciting international symposium exploring cutting-edge research in synapse biology, featuring world-renowned experts from prestigious institutes. This event will dive into key topics such as: · Molecular Studies of the Synapse · Synaptic Vesicle States · Neuromodulation · Long Range Plasticity in the Nervous System · Diseases of the Nervous System · Neuronal Cell Biology · Molecular Mechanisms of Neurotransmitter Release · Sensory Processing The symposium provides a platform for both leading scientists and junior researchers, including PhD students, postdocs, and students in Neuroscience and related fields, to engage and collaborate. Venue: Panum Institute, University of Copenhagen Set in the heart of Copenhagen, surrounded by the beautiful sites of this Scandinavian capital. Networking Opportunities: Reception: On the first evening, a reception will be held for all attendees to encourage networking and exchange of ideas. Poster Sessions: Present your research and engage with peers. Short Talks: Selected from submitted abstracts. Dinner: For speakers of invited speakers. This is a unique opportunity to connect with experts at the forefront of neuroscience research. We look forward to welcoming you to Copenhagen! Click here to sign up! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1721723650630-F46CP7S0BKEFEEMFVRHS/image-asset.jpeg News - Lab Outing Summer 2024 We had a wonderful lab outing canoeing north of Copenhagen!The weather was very nice while we canoed, and in classic Copenhagen fashion, it began to rain as soon as we finished, we lucked out! It was fun to watch us learn to canoe with each other and adapt to how we paddled around, a very "hygge" experience. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1718973337337-4966NX70Y4DQ3M10DZP9/image-asset.jpg News - Dr. Manon Berns and Simona Buccolo Defended Their Theses We at the Walter Lab would like to congratulate Dr. Manon Berns for an amazing defense of her Ph.D. Dissertation on the "Molecular Mechanisms of Synaptic Transmission Investigated Using Mathematical Models". She has worked so hard these last few years, and it's no surprise she has achieved her Doctorate! We wish her the best to her and her future endeavors. We would also like to congratulate Simona Buccolo M.Sc. for successfully defending her Masters Thesis on "Molecular and Cellular Mechanisms Regulating Presynaptic Homeostatic Potentiation". Congratulations to both again for their hard work and dedication! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1714983043261-TJU994LDOEX2T0HBVB5K/lax%2B90632_elife-90632-fig2-v1.tif.jpg News - Our paper on Syt7 is now available on eLife Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release Using electrophysioloygy, electro microscopy, fluoresence imaging, and mathematical modeling, we find that Doc2alpha is the major Ca2+ sensor for asynchronous release, while Sytnaptotagmin7 play a supporting role in this release via docking mechanisms Read more here! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1686559036796-CWDF60QL0CSRFP0YYW8Y/Screenshot+2023-06-12+102623.png News - Our work on Unc13A is now published in Cell reports Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation. Using a combination of electrophysiological recordings, STED microscopy and Mathematical modelling we showed that Ca2+-Calmodulin binding to Unc13A enhances neurotransmitter release-site occupation through its subsynaptic redistribution. In this way Unc13A plays a role in short-term facilitation and homeostatic potentiation. Enjoy reading the work https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1721724369915-ZERV4XLPKUW88EBNVBQ5/image-asset.jpeg News - Lab Outing Summer 2023 We had a wonderful time exploring the Louisiana Museum of Modern Art in Humlebæk, and enjoyed the lovely early May weather. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1682930300880-8N4FG0RBHYVJ179IKXJM/image-asset.jpeg News - LundBeckFonden grant for Kavya! Kavya Vinayan Pushpalatha received a Lundbeck Foundation grant to study the molecular mechanisms of presynaptic long-term plasticity and its implications in synaptopathy. find the press release here https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1682930450394-QYN92E5HBYYBLL8EBHAK/image-asset.jpeg News - New article is published in Frontiers in cellular neuroscience We proudly present our publication: Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials We showed that the level of spontaneous activity of an active zone is a predictor of the active zone’s responsiveness to action potential stimulation. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1671529005566-C8K370FCH7WLOIAAEJRO/image-asset.png News - Alex received the ERC consolidator grant! See the deparments news article https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661427659176-VJMVNGTGX5SWB6BB26QQ/StrikingImage.png News https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1667830370220-N64XXM2BVB6BJV45NKGR/image-asset.png News - Culture night 2022 On Friday the 14th of October, people could learn everything about our research using the fruit and computational models during Copenhagen’s annual culture night. They could go through the several steps of building a model using Lego, take a closer look at flies under the microscope and learn that flies are not just annoying during a science talk. It was great sharing our research to the public. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661427659176-VJMVNGTGX5SWB6BB26QQ/StrikingImage.png News - Our mathematical model of synaptotagmin-1 is now published in eLife We proudly present our newest publication in eLife Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis Using a mathematical model, we show that the allosteric interaction between calcium and PI(4,5)P2 binding sites of synaptotagmin-1 is crucial to explain the role syt1 has as the calcium sensor for synchronous neurotransmitter release. The model predicted that approximately three syts are active during fast exocytosis. Have fun reading it and check out our other publications! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661429369238-EMGOV6CZ4HTQIIL8GBGO/image-asset.jpeg News - From the lab to the boat We started our summer event/Lab outing on the idyllic canals of Copenhagen, with plenty of food, drinks and good company. Afterwards we enjoyed games in the park and finished our day with an international dinner at Alex’s place. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661428134918-KAN2SVFVI1J2CQ2U55B9/MeidaandRukiye.png News - Meida and Rukiye have defended their theses We are happy to announce that our former PhD students from Berlin Meida and visiting scientist Rukiye have successfully finished their doctoral studies. Congratulations! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1661430400563-RNYTUQ9SV8MIY3LR3MO0/image-asset.jpeg News - Manon presented at DIM the brain In this talk, Manon discussed our modelling study on the calcium sensor synaptotagmin DIM the brain is a seminar series at SUND, university of Copenhagen https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1632123393600-3WOX4P5AMC6TTXQFO24H/group+cph.jpg News - We moved to Copenhagen! This summer we moved to Copenhagen as a new group at the department of Neuroscience at the University of Copenhagen, Denmark. We are looking forward to continuing our work here and to all new collaborators. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1576331350775-N9FGHLJE039ZT0MMGPCA/image.jpg News - We have a new publication in Glia Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function In this work, we show that glial synaptobrevin is crucial to insulate and metabolically supply neurons. Impairment of this glially expressed synaptobrevin also affects motor neuron function in the Drosophilla larvea. Have fun reading! See our publication page for more publications https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1592552152333-AAMCGUPUC4BNTLBF00G6/image-asset.jpeg News - Anthony & Andreas have defended their theses We are happy to announce that our former PhD students Anthony and Andreas have successfully finished their doctoral studies. Congratulations! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1578392462482-SL9Y8KKODJ0AQV36MN1W/image-asset.jpeg News - Our lab has moved to the University of Copenhagen! Following the call for Alex to become a Professor at the University of Copenhagen, the lab has now relocated from Berlin. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1576327906220-VJMVPZWUCTEB2P0M14FD/image-asset.jpeg News - We have a new publication in PNAS! Resulting from a joint effort with the lab of André Nadler in Dresden, we present our newest publication in PNAS: Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities For this publication, we investigated lipid-protein affinities and the transbilayer dynamics of different DAG-species by combining lipid uncaging and mathematical modelling. Have fun reading it and check out our other publications! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1576327393324-JQJZWD8HIC8GCTKKTUG6/image-asset.jpeg News - We have a new paper in eLife! After a good amount of experiments and simulations, we are happy to announce our newest publication in eLife: Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances In this work, we explain how synaptic vesicles are heterogeneously distributed in regard to Calcium sources, and why synapses can only achieve the necessary facilitation when unpriming is inhibited in a Calcium-dependent manner. Have fun reading it and check out our other publications! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1580311527233-M0NE8V300U3LFPW59ZWP/image-asset.jpeg News - We launched our new website! If you are reading this, you probably know. Welcome to our new site and enjoy browsing! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1580312372626-APNTRDSHWDPUKIAUQ8E4/image-asset.jpeg News - We have a new publication in Nature Communications! Our latest work has been published today: Rapid active zone remodeling consolidates presynaptic potentiation Here, we show how active zone components serve to regulate synaptic strength, and even short-term memory. Have fun reading it and check out our other publications! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1580312608019-3O5FPHNPQCWS225ANGKG/image-asset.jpeg News - Our latest review was published in FEBS letters! In our review “Regulation of synaptic release-site Ca2+ channel coupling as a mechanism to control release probability and short-term plasticity” we discuss recent work on synaptic coupling properties. Have fun reading it and check out our other publications! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1580285649701-WP8HZPFYEEG35SUTI3UT/image-asset.jpeg News - Best talk award for Mathias! At the MDC PostDoc day today, Mathias was awarded a prize for the best talk. Congratulations Mathias! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1580286013198-BT1YLVF07NIEG0QA3PFE/image-asset.jpeg News - Poster prize for Andreas! At the EMBO Workshop “Exocytosis and endocytosis: From synaptic vesicles to nanodiscs“ in Tenerife, Andreas was awarded the 1st Poster prize. Congratulations Andreas! https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1718973225939-XQYMDOIREBZJP3GF4EMN/Simona+and+Manon.jpg News https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1718973297864-JZ6QHMRHA5H7K5K327FO/Simona+and+Manon.jpg News https://www.walter-lab.com/preprints daily 0.75 2026-07-26 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1785019780581-SCEV8TSGL3EW5CVT6YWO/image-asset.jpg Preprints - Functional relevance of mobile and clustered CaV2.1 channels in central synapses Abderazzaq K.E, Amaral C., Lassen A.S., Weißbach S., Werkmann C., Bikbaev A., Mark M.D., Herlitze S., Heck J., Walter A.M., and Martin Heine under review at Science Advances. Preprint on BioRXi. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1671529525348-KQ5JJUN4B9YRW9355D9R/image-asset.png Preprints - Release site plasticity via Unc13A regulatory domains mediates synaptic short-term facilitation and homeostatic potentiation BioRxiv, November 2022 Meida Jusyte, Natalie Blaum, Mathias A. Böhme, Manon M. M. Berns, Alix E. Bonard, Janus R. L. Kobbersmed, Alexander M. Walter https://www.walter-lab.com/disease daily 0.75 2026-07-26 https://www.walter-lab.com/publications daily 0.75 2026-07-26 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1576322968304-HGADK1QRW1GR14YDJW09/image-asset.jpeg Publications https://www.walter-lab.com/lab-news daily 0.75 2021-09-01 https://www.walter-lab.com/404-error-custom-page daily 0.75 2020-02-01 https://www.walter-lab.com/new-page-3 daily 0.75 2024-08-07 https://www.walter-lab.com/alumni daily 0.75 2026-07-25 https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/9c71ea9f-3329-4755-bee4-ce83863b7e6e/lab2022IMG_1595.webp Alumni - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d8c9ec3b7b88e4b013c2193/1b2e765d-01d3-443b-bc14-78c291d5daaa/lab2019.webp Alumni - Make it stand out Whatever it is, the way you tell your story online can make all the difference.